SPACE PHARMACOKINETICS PREDICTION PLATFORM

Predicting Drug Behavior Beyond Earth

๋ฏธ์„ธ์ค‘๋ ฅ ํ™˜๊ฒฝ์—์„œ์˜ ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ
์•ฝ๋ฌผ๋™ํƒœํ•™(PK)์˜ ๋ณ€ํ™”๋ฅผ ์˜ˆ์ธกํ•˜๋Š” ์‹œ๋ฎฌ๋ ˆ์ด์…˜ ํ”Œ๋žซํผ

4 Environments
PBPK Model Based
Real-time Simulation
Launch Simulator Explore Environments
Earth
ISS
Moon
Mars
Earth
9.81 m/sยฒ
ISS
~0 m/sยฒ (microgravity)
Moon
1.62 m/sยฒ
Mars
3.72 m/sยฒ

EXPLORATION TARGETS

ํ™˜๊ฒฝ๋ณ„ ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”

์ค‘๋ ฅ ์ฐจ์ด์— ๋”ฐ๋ฅธ ์ธ์ฒด ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”์™€ ์•ฝ๋™ํ•™ ํŒŒ๋ผ๋ฏธํ„ฐ ์˜ํ–ฅ

๐ŸŒ

Earth

1.0 G

๊ธฐ์ค€ ํ™˜๊ฒฝ (Baseline)

โค๏ธ
์‹ฌํ˜ˆ๊ด€๊ณ„ ์ •์ƒ ์‹ฌ๋ฐ•์ถœ๋Ÿ‰ ~5 L/min
๐Ÿซ
์ฒด์•ก ๋ถ„ํฌ ์ •์ƒ ์ค‘๋ ฅ ์˜์กด์  ๋ถ„ํฌ
๐Ÿงฌ
๊ฐ„ ๋Œ€์‚ฌ CYP450 ์ •์ƒ ํ™œ์„ฑ
๐Ÿ’ง
์‹ ์žฅ ๊ธฐ๋Šฅ GFR ~120 mL/min
BASELINE ๋ชจ๋“  PK ํŒŒ๋ผ๋ฏธํ„ฐ ๊ธฐ์ค€๊ฐ’
๐Ÿ›ธ

ISS

~0 G

๋ฏธ์„ธ์ค‘๋ ฅ ํ™˜๊ฒฝ (Microgravity)

โค๏ธ
์‹ฌํ˜ˆ๊ด€๊ณ„ ์‹ฌ๋ฐ•์ถœ๋Ÿ‰ โ†“ 15~20%, ์‹ฌ์žฅ ๋ฆฌ๋ชจ๋ธ๋ง
๐Ÿซ
์ฒด์•ก ๋ถ„ํฌ ํ˜„์ €ํ•œ ๋‘๋ถ€ ๋ฐฉํ–ฅ ์ฒด์•ก ์ด๋™, ์šฐ์ฃผ ๋นˆํ˜ˆ
๐Ÿงฌ
๊ฐ„ ๋Œ€์‚ฌ ๊ฐ„ ํ˜ˆ๋ฅ˜ โ†“โ†“ โ†’ CYP ํ™œ์„ฑ ํ˜„์ €ํžˆ ๋ณ€ํ™”
๐Ÿ’ง
์‹ ์žฅ ๊ธฐ๋Šฅ GFR โ†“ 22%, ์‹ ํ˜ˆ๋ฅ˜๋Ÿ‰ ํ˜„์ €ํžˆ ๊ฐ์†Œ
SEVERE IMPACT ๊ฐ€์žฅ ๊ทน๋‹จ์ ์ธ PK ๋ณ€ํ™”, ์šฉ๋Ÿ‰ ์žฌ์„ค๊ณ„ ํ•„์ˆ˜
๐ŸŒ™

Moon

0.16 G

์ €์ค‘๋ ฅ ํ™˜๊ฒฝ

โค๏ธ
์‹ฌํ˜ˆ๊ด€๊ณ„ ์‹ฌ๋ฐ•์ถœ๋Ÿ‰ โ†“ 10~15%
๐Ÿซ
์ฒด์•ก ๋ถ„ํฌ ๋‘๋ถ€ ๋ฐฉํ–ฅ ์ฒด์•ก ์ด๋™ (fluid shift)
๐Ÿงฌ
๊ฐ„ ๋Œ€์‚ฌ ๊ฐ„ ํ˜ˆ๋ฅ˜ โ†“ โ†’ CYP ํ™œ์„ฑ ๋ณ€ํ™”
๐Ÿ’ง
์‹ ์žฅ ๊ธฐ๋Šฅ GFR โ†‘ ์ดˆ๊ธฐ ํ›„ โ†“ ์ ์‘
MODERATE IMPACT Vd โ†‘, CL ๋ณ€ํ™”, tยฝ ์—ฐ์žฅ ๊ฐ€๋Šฅ
๐Ÿ”ด

Mars

0.38 G

๋ถ€๋ถ„ ์ค‘๋ ฅ ํ™˜๊ฒฝ

โค๏ธ
์‹ฌํ˜ˆ๊ด€๊ณ„ ์‹ฌ๋ฐ•์ถœ๋Ÿ‰ โ†“ 5~10%
๐Ÿซ
์ฒด์•ก ๋ถ„ํฌ ๋ถ€๋ถ„์  fluid shift
๐Ÿงฌ
๊ฐ„ ๋Œ€์‚ฌ ๊ฐ„ ํ˜ˆ๋ฅ˜ ๊ฒฝ๋ฏธํ•œ โ†“
๐Ÿ’ง
์‹ ์žฅ ๊ธฐ๋Šฅ GFR ๊ฒฝ๋ฏธํ•œ ๋ณ€ํ™”
MILD IMPACT Earth์™€ Moon ์‚ฌ์ด ์ค‘๊ฐ„ ๋ณ€ํ™”

PHARMACOKINETIC PARAMETERS

์ฃผ์š” PK ํŒŒ๋ผ๋ฏธํ„ฐ ๋ณ€ํ™” ์˜ˆ์ธก

Absorption (ka)

์œ„์žฅ๊ด€ ์šด๋™์„ฑ ๋ณ€ํ™”,
์œ„ ๋ฐฐ์ถœ ์‹œ๊ฐ„ ์ง€์—ฐ

Earth: Baseline ISS: โ†“ 45~50% Moon: โ†“ 20~40% Mars: โ†“ 10~20%

Distribution (Vd)

์ฒด์•ก ์ด๋™, ํ˜ˆ์žฅ๋Ÿ‰ ๋ณ€ํ™”,
์กฐ์ง ๊ด€๋ฅ˜ ๋ณ€ํ™”

Earth: Baseline ISS: โ†‘ 25~40% Moon: โ†‘ 15~30% Mars: โ†‘ 5~15%

Metabolism (CLH)

๊ฐ„ ํ˜ˆ๋ฅ˜๋Ÿ‰ ๊ฐ์†Œ,
CYP450 ํšจ์†Œ ํ™œ์„ฑ ๋ณ€ํ™”

Earth: Baseline ISS: โ†“ 25~35% Moon: โ†“ 15~25% Mars: โ†“ 5~15%

Excretion (CLR)

์‹ ํ˜ˆ๋ฅ˜๋Ÿ‰ ๋ณ€ํ™”,
์‚ฌ๊ตฌ์ฒด ์—ฌ๊ณผ์œจ ๋ณ€ํ™”

Earth: Baseline ISS: โ†“ 20~25% Moon: โ†“ 10~20% Mars: โ†“ 5~10%

ABOUT ASTROPK

์ง€๊ตฌ ๋„ˆ๋จธ,
์น˜๋ฃŒ์˜ ์ง€ํ‰์„ ์—ด๋‹ค

"The cosmos is within us. We are made of star-stuff.
We are a way for the universe to know itself."
โ€” Carl Sagan
01

์ƒˆ๋กœ์šด ์‹œ๋Œ€, ์ƒˆ๋กœ์šด ๋„์ „

์ธ๋ฅ˜๋Š” ์ง€๊ธˆ, ์ง€๊ตฌ๋ผ๋Š” ์š”๋žŒ์„ ๋ฒ—์–ด๋‚˜ ์šฐ์ฃผ๋กœ ํ–ฅํ•˜๋Š” ๊ฑฐ๋Œ€ํ•œ ์ „ํ™˜์ ์— ์„œ ์žˆ์Šต๋‹ˆ๋‹ค. ๋‹ฌ ๊ธฐ์ง€ ๊ฑด์„ค, ํ™”์„ฑ ์œ ์ธ ํƒ์‚ฌ, ๊ทธ๋ฆฌ๊ณ  ์žฅ๊ธฐ ์šฐ์ฃผ ๊ฑฐ์ฃผ โ€” ์ด ๋ชจ๋“  ๊ฒƒ์ด ๋” ์ด์ƒ ๊ณต์ƒ์ด ์•„๋‹Œ ํ˜„์‹ค์˜ ๋กœ๋“œ๋งต ์œ„์— ๋†“์—ฌ ์žˆ์Šต๋‹ˆ๋‹ค. ํ•˜์ง€๋งŒ ์ด ์œ„๋Œ€ํ•œ ๋„์ „์˜ ์ด๋ฉด์—๋Š” ์•„์ง ๋‹ตํ•˜์ง€ ๋ชปํ•œ ๊ทผ๋ณธ์ ์ธ ์งˆ๋ฌธ์ด ์กด์žฌํ•ฉ๋‹ˆ๋‹ค.

02

์ง€๊ตฌ์˜ ์•ฝ, ์šฐ์ฃผ์—์„œ๋„ ํ†ตํ• ๊นŒ?

๋ฏธ์„ธ์ค‘๋ ฅ์€ ์ธ์ฒด๋ฅผ ๊ทผ๋ณธ์ ์œผ๋กœ ๋ณ€ํ™”์‹œํ‚ต๋‹ˆ๋‹ค. ์ฒด์•ก์€ ์ƒ์ฒด๋กœ ์ด๋™ํ•˜๊ณ , ์‹ฌํ˜ˆ๊ด€๊ณ„๋Š” ์žฌ์ ์‘ํ•˜๋ฉฐ, ๊ฐ„๊ณผ ์‹ ์žฅ์˜ ํ˜ˆ๋ฅ˜๊ฐ€ ๋‹ฌ๋ผ์ง‘๋‹ˆ๋‹ค. ์ด ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”๋Š” ๊ณง ์•ฝ๋ฌผ์ด ํก์ˆ˜๋˜๊ณ , ๋ถ„ํฌํ•˜๊ณ , ๋Œ€์‚ฌ๋˜๊ณ , ๋ฐฐ์„ค๋˜๋Š” ๋ชจ๋“  ๊ณผ์ • โ€” ์ฆ‰ ์•ฝ๋ฌผ๋™ํƒœํ•™(Pharmacokinetics)์˜ ๋ณ€ํ™”๋ฅผ ์˜๋ฏธํ•ฉ๋‹ˆ๋‹ค. ์ง€๊ตฌ์—์„œ ๊ฒ€์ฆ๋œ ์šฉ๋ฒ•ยท์šฉ๋Ÿ‰์ด ์šฐ์ฃผ์—์„œ๋Š” ๋” ์ด์ƒ ์ตœ์ ์ด ์•„๋‹ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค.

03

AstroPK๊ฐ€ ๋˜์ง€๋Š” ์งˆ๋ฌธ

AstroPK๋Š” ์ด ์งˆ๋ฌธ์— ๊ณผํ•™์ ์œผ๋กœ ์ ‘๊ทผํ•˜๊ธฐ ์œ„ํ•ด ํƒ„์ƒํ–ˆ์Šต๋‹ˆ๋‹ค. ์ง€๊ตฌ(1G), ISS(~0G), ๋‹ฌ(0.16G), ํ™”์„ฑ(0.38G) โ€” ์„œ๋กœ ๋‹ค๋ฅธ ์ค‘๋ ฅ ํ™˜๊ฒฝ์—์„œ์˜ ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”๋ฅผ PBPK ๋ชจ๋ธ์— ๋ฐ˜์˜ํ•˜์—ฌ, ์•ฝ๋ฌผ์˜ ์ฒด๋‚ด ๊ฑฐ๋™์ด ์–ด๋–ป๊ฒŒ ๋‹ฌ๋ผ์ง€๋Š”์ง€๋ฅผ ์˜ˆ์ธกํ•ฉ๋‹ˆ๋‹ค. ๊ตญ์ œ์šฐ์ฃผ์ •๊ฑฐ์žฅ(ISS)์˜ ๋ฏธ์„ธ์ค‘๋ ฅ๋ถ€ํ„ฐ ํ™”์„ฑ์˜ ๋ถ€๋ถ„ ์ค‘๋ ฅ๊นŒ์ง€, ์šฐ์ฃผ ํ™˜๊ฒฝ์— ์ตœ์ ํ™”๋œ ํˆฌ์—ฌ ์ „๋žต์„ ์„ค๊ณ„ํ•˜๋Š” ์ฒซ๊ฑธ์Œ์„ ๋‚ด๋”›๊ณ ์ž ํ•ฉ๋‹ˆ๋‹ค.

04

์น˜๋ฃŒ์˜ ์šฐ์ฃผ์  ํ™•์žฅ

์ด๊ฒƒ์€ ๋‹จ์ˆœํ•œ ์‹œ๋ฎฌ๋ ˆ์ด์…˜ ๋„๊ตฌ๊ฐ€ ์•„๋‹™๋‹ˆ๋‹ค. ์ธ๋ฅ˜๊ฐ€ ๋‹ค์ค‘ํ–‰์„ฑ ์ข…(multi-planetary species)์œผ๋กœ ์ง„ํ™”ํ•˜๋Š” ์—ฌ์ •์—์„œ, ๋ชจ๋“  ๊ณณ์—์„œ ๋ชจ๋“  ์‚ฌ๋žŒ์ด ์ ์ ˆํ•œ ์น˜๋ฃŒ๋ฅผ ๋ฐ›์„ ์ˆ˜ ์žˆ๋Š” ๋ฏธ๋ž˜๋ฅผ ํ–ฅํ•œ ๋„์ „์ž…๋‹ˆ๋‹ค. AstroPK๋Š” ์šฐ์ฃผ ์˜ํ•™(Space Medicine)๊ณผ ์•ฝ๋ฌผ๋™ํƒœํ•™์˜ ๊ต์ฐจ์ ์—์„œ, ์น˜๋ฃŒ์˜ ์ง€ํ‰์„ ์ง€๊ตฌ ๋„ˆ๋จธ๋กœ ํ™•์žฅํ•˜๋Š” ์ฒซ ๋ฒˆ์งธ ๋ฐœ๊ฑธ์Œ์ž…๋‹ˆ๋‹ค.

Predict

์ค‘๋ ฅ ํ™˜๊ฒฝ๋ณ„ ์ƒ๋ฆฌํ•™์  ๋ณ€ํ™”๋ฅผ ๋ฐ˜์˜ํ•œ PK ํŒŒ๋ผ๋ฏธํ„ฐ ์˜ˆ์ธก

Optimize

ํ™˜๊ฒฝ์— ์ตœ์ ํ™”๋œ ์•ฝ๋ฌผ ํˆฌ์—ฌ ์ „๋žต ์„ค๊ณ„ ๋ฐ ์‹œ๋ฎฌ๋ ˆ์ด์…˜

Expand

์šฐ์ฃผ ์˜ํ•™ ์—ฐ๊ตฌ๋ฅผ ํ†ตํ•œ ์น˜๋ฃŒ์˜ ์ง€ํ‰ ํ™•์žฅ

FRONTIER

๋„์ „ํ•˜๋Š” ์‚ฌ๋žŒ๋“ค

์šฐ์ฃผ ์•ฝ๋ฌผ๋™ํƒœํ•™์˜ ์ตœ์ „์„ ์—์„œ ์ƒˆ๋กœ์šด ์ง€ํ‰์„ ์—ฌ๋Š” ์—ฐ๊ตฌ์ž๋“ค

Kyeong-Ryoon Lee, Ph.D.

Moonkyu Jeong

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์•ฝ๋ฌผ์„ ์„ ํƒํ•˜๊ณ , ํ™˜๊ฒฝ์„ ์„ค์ •ํ•˜์—ฌ
์šฐ์ฃผ์—์„œ์˜ ์•ฝ๋™ํ•™ ๋ณ€ํ™”๋ฅผ ์‹œ๋ฎฌ๋ ˆ์ด์…˜ํ•ด ๋ณด์„ธ์š”

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